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| 产品信息 | |
|---|---|
| 描述 | Recombinant Mouse Interferon gamma is produced by our E.coli expression system and the target gene encoding His23-Cys155 is expressed. |
| 别名 | Ifng; Interferon gamma; IFN-gamma |
| 来源 | Escherichia coli. |
| 分子量 | 15.5 kd |
| 形态 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 纯度 | Greater than 95% as determined by reducing SDS-PAGE. |
| 内毒素水平 | Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test. |
| 活性 | Determined by its ability to inhibit the proliferation of murine WEHI-279 cells. The ED50 for this effect is 1 ng/ml. |
| 溶解方法 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| 储存/保存方法 | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| 背景说明 | Mouse Ifng is a secreted protein which belongs to the type I I (or gamma) interferon family. IFNG is produced by lymphocytes and activated by specific antigens or mitogens. In addition to having antiviral activity, IFNG also has important immunoregulatory functions. It is a potent activator of macrophages and has antiproliferative effects on transformed cells. It can potentiate the antiviral and antitumor effects of the type I interferons. Genetic variation in IFNG is associated with the risk of aplastic anemia (AA) which is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis. |
| Accession | P01580 |
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